Background/Aims. Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC). In addition,\nthere may be an association between leukemia and lymphoma and IBD.We conducted a systematic review and meta-analysis of the\nIBD literature to estimate the incidence of CRC, leukemia, and lymphoma in adult IBD patients. Methods. Studies were identified\nby a literature search of PubMed, Cochrane Library, Medline,Web of Science, Scopus, EMBASE, and ProQuest Dissertations and\nTheses. Pooled incidence rates (per 100,000 person-years [py]) were calculated through use of a random effects model, unless\nsubstantial heterogeneity prevented pooling of estimates. Several stratified analyses and meta regression were performed to explore\npotential study heterogeneity and bias. Results. Thirty-six articles fulfilled the inclusion criteria. For CRC, the pooled incidence rate\nin CD was 53.3/100,000 py (95% CI 46.3ââ?¬â??60.3/100,000). The incidence of leukemia was 1.5/100,000 py (95% CI âË?â??0.06ââ?¬â??3.0/100,000)\nin IBD, 0.3/100,000 py (95% CI âË?â??1.0ââ?¬â??1.6/100,000) in CD, and 13.0/100,000 py (95% CI 5.8ââ?¬â??20.3/100,000) in UC. For lymphoma,\nthe pooled incidence rate in CD was 0.8/100,000 py (95% CI âË?â??0.4ââ?¬â??2.1/100,000). Substantial heterogeneity prevented the pooling of\nother incidence estimates. Conclusion.The incidence of CRC, leukemia, and lymphoma in IBD is low.
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